Rethinking Early Airway Clearence Therapies

Starting soon · Not applicable

Conditions studied: Cystic Fibrosis (CF)

In brief

The REACT trial consists of two parallel, randomized studies; the Hypertonic Saline Study and the Dornase Alfa Study. Health outcomes among people with cystic fibrosis (CF) have been steadily improving, most recently with the advent of highly effective modulator therapy (HEMT). While therapies like hypertonic saline (HS) and dornase alfa (DA) improved outcomes in the past, they are often burdensome. Now that almost 90% of the North American CF population is being treated with elexacaftor/tezacaftor/ivacaftor (ETI) or vanzacaftor/tezacaftor/deutivacaftor (VTD), this trial will evaluate whether these newer treatments make daily HS or DA unnecessary. The trial begins with a 6-week run-in period where participants continue ETI or VTD but stop using HS and DA. Eligible participants are then assigned to either the HS Study or the DA Study for one year. Within those groups, they are randomized to either daily use of HS or DA or as needed use only during respiratory illnesses. The study aims to find out if lung health is similar between children and teens taking HEMT who use HS or DA treatments daily and those who use HS or DA treatments only when they are sick.

Key facts

Study ID

NCT07696338

Run by

Nicole Hamblett

People needed

405

Starts

2026-09-15

Expected to finish

2030-02-28

Last updated by the study team

2026-07-10

Who can join

Age: 3 and older, up to 16. Sex: any. Healthy volunteers: not accepted.

Where it is running

• The Children's Hospital Alabama, University of Alabama at Birmingham — Birmingham, Alabama, United States
• Tucson Cystic Fibrosis Center — Tucson, Arizona, United States
• Childrens Hospital Los Angeles — Los Angeles, California, United States
• CHOC Children's Hospital — Orange, California, United States
• Stanford University Medical Center — Palo Alto, California, United States
• Children's Hospital Colorado — Aurora, Colorado, United States
• All Children's Hospital — St. Petersburg, Florida, United States
• Children's Healthcare of Atlanta and Emory University — Atlanta, Georgia, United States
• Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
• Riley Hospital for Children — Indianapolis, Indiana, United States
• University of Iowa — Iowa City, Iowa, United States
• John Hopkins Hospital — Baltimore, Maryland, United States
• Boston Children's Hospital — Boston, Massachusetts, United States
• University of Michigan, Michigan Medicine — Ann Arbor, Michigan, United States
• Children's Hospitals and Clinics of Minnesota — Minneapolis, Minnesota, United States
• The Minnesota Cystic Fibrosis Center — Minneapolis, Minnesota, United States
• Children's Mercy Kansas City — Kansas City, Missouri, United States
• St. Louis Children's Hospital — St Louis, Missouri, United States
• University of Rochester Medical Center Strong Memorial — Rochester, New York, United States
• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
• Nationwide Children's Hospital — Columbus, Ohio, United States
• Dayton Children's Hospital — Dayton, Ohio, United States
• Oregon Health & Sciences University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.