Micronutrient Enhancement for Development and Health in Adolescents - The MEDHA Study

Starting soon · Phase 3 · Has a placebo group

Conditions studied: Neurodevelopment Outcome, Linear Growth, Micronutrient Status, Bone Mineral Density, Underweight, Stunting, Body Composition, Blood Pressure, HRQOL (Health Related Quality Of Life), Waist-to-height Ratio

In brief

MEDHA is a randomized controlled trial among 10-18 year old girls to examine the use-case of the United Nations International Multiple Micronutrient Antenatal Preparation (UNIMMAP) multiple micronutrient supplement (MMS) formulation and to test an enhanced regimen (MMS+) with additional nutrients, vs. weekly iron-folic acid as standard of care on outcomes of neurodevelopment, linear growth, biochemical status, bone health, and other functional and health outcomes. This study is an individually randomized, open-label, three-arm trial of 3,000 participants supplemented for 12 months to assess the efficacy and safety of nutrient supplementation. Results of the study will inform the design of nutritional interventions and policy for this age group. In the context of the trial, the investigators will also do in-depth clinical and health assessments and collect biospecimens for a bio-archive for future deep-phenotyping of this population. This study will be conducted at the Johns Hopkins Bangladesh JiVitA field site in rural Gaibandha District of Bangladesh.

Key facts

Study ID

NCT07695883

Run by

Johns Hopkins Bloomberg School of Public Health

People needed

3000

Starts

2026-09-01

Expected to finish

2028-06-30

Last updated by the study team

2026-08-06

Who can join

Age: 10 and older, up to 18. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Unmarried 10-18 year old females
• living in their parental home in the study area

You may not qualify if…

• Married females under 18 years old;
• those with a history or diagnosis of chronic or congenital heart disease, chronic kidney or lung disease, cancer, and epilepsy

Where it is running

• JiVitA Project Head Quarters — Rangpur City, Bangladesh

Full record on ClinicalTrials.gov

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