Targeting GLUT1 to Control Autoimmunity in Type 1 Diabetes

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Conditions studied: Type 1 Diabetes, Autoimmunity

In brief

Type 1 Diabetes is an autoimmune disease in which immune cells contribute to the destruction of insulin-producing pancreatic beta cells. This study investigates whether targeting glucose transporter 1 (GLUT1), a transporter involved in immune cell metabolism, may help modulate autoimmune responses associated with Type 1 Diabetes. The study uses previously collected and biobanked peripheral blood mononuclear cells (PBMCs) from individuals with Type 1 Diabetes. No additional visits, blood draws, or study-specific procedures will be performed on human participants.

Key facts

Study ID

NCT07695727

Run by

IRCCS San Raffaele

People needed

84

Starts

2026-09-01

Expected to finish

2029-09-01

Last updated by the study team

2026-07-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• PBMC samples obtained from adult subjects aged 18 years or older at the time of sample collection.
• Documented diagnosis of Type 1 Diabetes.
• PBMC samples already collected and stored in the institutional Biobank of IRCCS Ospedale San Raffaele.
• PBMC samples obtained from subjects who had previously provided written informed consent for the collection, storage, and research use of biological material and associated data.

You may not qualify if…

• PBMC samples obtained from subjects younger than 18 years at the time of sample collection.
• Presence of relevant concomitant diseases or clinical conditions that, in the Investigator's judgment and based on available records, may interfere with the interpretation of immunological analyses or with the study objectives.
• Insufficient sample availability, inadequate sample quality, or missing essential sample-related information preventing use of the PBMC sample for the planned research activities.

Where it is running

• IRCCS San Raffaele Scientific Institute — Milan, Italy

Full record on ClinicalTrials.gov

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