The Predictive Value of Lower Extremity Hypertonia on Neurogenic Detrusor Overactivity After Spinal Cord Injury
Starting soon
Conditions studied: Spinal Cord Injuries (SCI)
In brief
The goal of this observational study is to evaluate whether increased lower extremity muscle tone can serve as an independent predictor of neurogenic detrusor overactivity (NDO) in adult patients (aged 18-80 years) with upper sacral spinal cord injury . The main questions it aims to answer are: Is increased lower extremity muscle tone independently associated with the presence of detrusor overactivity after adjusting for age, sex, injury level, injury type, and injury cause? Does the predictive value of muscle tone for detrusor overactivity differ across subgroups defined by injury level, injury severity, and time since injury? Researchers will compare patients with lower extremity hypertonia (Modified Ashworth Scale ≥ 1) to patients with normal muscle tone (Modified Ashworth Scale = 0) to see if muscle tone elevation independently predicts detrusor overactivity. Participants will not be asked to do anything beyond their routine clinical care, as this is a retrospective study that only collects data from existing medical records, including neurological examination results, Modified Ashworth Scale scores, and urodynamic study reports.
Key facts
- Study ID
- NCT07695662
- Run by
- Shengjing Hospital
- People needed
- 300
- Starts
- 2026-07-07
- Expected to finish
- 2027-06-14
- Last updated by the study team
- 2026-07-10
Who can join
Age: 16 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of spinal cord injury confirmed by CT or MRI imaging
- Suprasacral spinal cord injury according to the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI, 2011 revision)
- Age between 18 and 80 years
- Complete medical records, including detailed neurological examination, Modified Ashworth Scale assessment, and urodynamic study report
You may not qualify if…
- Critical missing information in medical records or urodynamic reports
- Interval between Modified Ashworth Scale assessment and urodynamic study exceeding 2 weeks
Full record on ClinicalTrials.gov
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