Lemborexant Use for Cognition Improvement in Postoperative Delirium in Elderly Patients: A Randomized Controlled Trial

Starting soon · Phase 2 · Has a placebo group

Conditions studied: Postoperative Delirium

In brief

This prospective, randomized controlled trial aims to investigate the perioperative use of lemborexant, an orexin receptor antagonist, for reducing postoperative delirium (POD) in elderly patients undergoing general anesthesia.

Key facts

Study ID

NCT07695285

Run by

Beijing Tiantan Hospital

People needed

992

Starts

2026-09-01

Expected to finish

2029-12-31

Last updated by the study team

2026-07-14

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥60 years old;
• ASA classification I to III;
• Patients undergoing elective surgery;
• Sign the informed consent form.

You may not qualify if…

• Tracheal intubation is expected to be retained after the operation;
• Previous history of alcohol or drug abuse;
• Severe abnormalities in liver and kidney functions;
• Long-term use of sedative-hypnotic drugs;
• Severe sleep apnea and COPD;
• Inability to cooperate in mental state;
• Craniocerebral surgery
• Pregnant and lactating patients;
• Use drugs that affect orexin metabolism.

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.