Effects of Proprioceptive Neuromuscular Facilitation and Task-Oriented Training on Upper Extremity Function in Children With Spastic Diplegic Cerebral Palsy

Recruiting now · Not applicable

Conditions studied: Cerebral Palsy, Spastic Diplegia

In brief

Children with spastic diplegic cerebral palsy often experience upper extremity impairments, including reduced coordination, muscle control, and functional hand use, which limit independence in daily activities. Proprioceptive Neuromuscular Facilitation (PNF) and Task-Oriented Training (TOT) are commonly used rehabilitation approaches to improve motor function; however, evidence comparing their individual and combined effects on upper extremity function remains limited. This randomized controlled trial aims to compare the effects of PNF alone, TOT alone, and a combined PNF plus TOT intervention on upper extremity function in children with spastic diplegic cerebral palsy. Sixty-three children aged 6 to 12 years with Gross Motor Function Classification System (GMFCS) levels I to III will be randomly assigned to one of three intervention groups. Each group will receive supervised 45-minute treatment sessions, three times per week for six weeks. Upper extremity function, functional independence, and joint range of motion will be assessed at baseline, mid-intervention (3 weeks), and post-intervention (6 weeks) using the Melbourne Assessment of Unilateral Upper Limb Function (MA2), Pediatric Evaluation of Disability Inventory-Functional Skills Scale (PEDI-FSS), and goniometric measurements. The findings of this study are expected to provide evidence regarding the most effective rehabilitation approach for improving upper extremity function in children with spastic diplegic cerebral palsy.

Key facts

Study ID: NCT07694804
Run by: Ibadat International University, Islamabad
People needed: 63
Starts: 2026-02-17
Expected to finish: 2026-07-08
Last updated by the study team: 2026-07-13

Who can join

Age: 6 and older, up to 12. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Children aged 6 to 12 years.
Clinical diagnosis of spastic diplegic cerebral palsy.
Gross Motor Function Classification System (GMFCS) Levels I-III.
Ability to understand and follow simple verbal instructions.
Medically stable and able to participate in physiotherapy sessions.
Parent or legal guardian willing to provide written informed consent.

You may not qualify if…

Orthopedic surgery involving the upper or lower extremities within the previous 6 months.
Botulinum toxin injections administered within the previous 6 months.
Severe visual, hearing, or cognitive impairments that would interfere with assessment or treatment.
Uncontrolled epilepsy or other unstable neurological or medical conditions.
Fixed upper extremity contractures or musculoskeletal deformities preventing participation in the intervention.
Participation in another structured upper extremity rehabilitation program during the study period.
Failure to obtain informed consent from a parent or legal guardian.

Where it is running

Helping Hand Institute of Rehabilitation — Mansehra, KPK, Pakistan (enrolling)

Full record on ClinicalTrials.gov

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