Clinical Multimodal Surveillance of Respiratory Syndrome Pathogens

Recruiting now

Conditions studied: Respiratory Tract Infections (RTI), Respiratory Syndrome, Acute, Severe, Acute Respiratory Infections (ARIs)

In brief

This nationwide, multicenter observational study will establish and improve a hospital-based clinical surveillance and early warning system for respiratory syndrome pathogens. Clinical data and biospecimens generated during routine care will be collected from participating medical institutions every two weeks to monitor pathogen trends, support risk assessment, and provide evidence for prevention and control measures.

Key facts

Study ID

NCT07694648

Run by

Huashan Hospital

People needed

2398

Starts

2025-09-01

Expected to finish

2028-09-30

Last updated by the study team

2026-07-10

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with respiratory syndrome: Eligible patients are those diagnosed with respiratory syndrome based on the predefined data dictionary and the following ICD-10 (International Statistical Classification of Diseases, 10th Revision) diagnosis codes: R05, R50, J00, J01, J02, J03, J04, J06, J07, J08, J09, J10, J11, J12, J13, J14, J15, J16, J17, J18, J20, J21, J98.414, and J98.802.
• Patients with respiratory syndrome: Eligible patients are identified using the following search criteria. Patients meeting any one of the following criteria should be included:
• Medical history (History of Present Illness): Positive test result for a respiratory syndrome-related pathogen.
• Laboratory testing: Positive test result for a respiratory syndrome-related pathogen.
• Medication: Receipt of any of the following antiviral agents:
• Nirmatrelvir/Ritonavir Leritrelvir Xiannuotewei/Ritonavir Molnupiravir Azvudine Deuremidevir
• Diagnosis: Diagnosis containing the term "respiratory tract infection."

You may not qualify if…

• Participants who may compromise the study results: Patients who are unable to provide a specimen or whose specimen volume is insufficient for laboratory testing.
• Participants who are unable to comply with study procedures.

Where it is running

• Beijing You'an Hospital, Capital Medical University — Beijing, Beijing Municipality, China (enrolling)
• The Fifth Affiliated Hospital of Guangzhou Medical University — Guangzhou, Guangdong, China (enrolling)
• The Fifth Affiliated Hospital of Sun Yat-sen University — Zhuhai, Guangdong, China (enrolling)
• The 980th Hospital of the People's Liberation Army Joint Logistics Support Force — Shijiazhuang, Hebei, China (enrolling)
• Heilongjiang Provincial Hospital — Harbin, Heilongjiang, China (enrolling)
• Jiamusi Central Hospital — Jiamusi, Heilongjiang, China (enrolling)
• Shangqiu Municipal Hospital — Shangqiu, Henan, China (enrolling)
• The First Affiliated Hospital of Zhengzhou University — Zhengzhou, Henan, China (enrolling)
• Yichang Third People's Hospital — Yichang, Hubei, China (enrolling)
• Hunan University of Medicine General Hospital — Huaihua, Hunan, China (enrolling)
• The Third Hospital of Baotou (Baotou City Hospital for Infectious Diseases) — Baotou, Inner Mongolia, China (enrolling)
• Nanjing Hospital of Chinese Medicine — Nanjing, Jiangsu, China (enrolling)
• The Third People's Hospital of Nantong (Nantong Hospital of Infectious Diseases) — Nantong, Jiangsu, China (enrolling)
• Wuxi Fifth People's Hospital — Wuxi, Jiangsu, China (enrolling)
• Jiujiang No.1 People's Hospital — Jiujiang, Jiangxi, China (enrolling)
• Shenyang Sixth People's Hospital — Shenyang, Liaoning, China (enrolling)
• Affiliated Hospital of Yan'an University — Yan’an, Shaanxi, China (enrolling)
• Zaozhuang Municipal Hospital — Zaozhuang, Shandong, China (enrolling)
• Huashan Hospital Fudan University — Shanghai, Shanghai Municipality, China (enrolling)
• Shanghai East Hospital — Shanghai, Shanghai Municipality, China (enrolling)
• Jinyang Community Health Service Center of Pudong New Area, Shanghai — Shanghai, Shanghai Municipality, China (enrolling)
• Shanghai Sixth People's Hospital — Shanghai, Shanghai Municipality, China (enrolling)
• Shanghai Pudong Hospital, Fudan University Affiliated Pudong Medical Center — Shanghai, Shanghai Municipality, China (enrolling)
• First Hospital of Shanxi Medical University — Taiyuan, Shanxi, China (enrolling)
• Children's Hospital of Shanxi Province — Taiyuan, Shanxi, China (enrolling)

Full record on ClinicalTrials.gov

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