Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis

Starting soon · Early Phase 1

Conditions studied: Cannabis Use, Tobacco, Biomarkers

In brief

This outpatient study examines how inhaled cannabis, combustible or vaporized, alters lung health and breath biomarkers compared to a tobacco cigarette.

Key facts

Study ID

NCT07694466

Run by

Hannah Harris

People needed

12

Starts

2026-09-01

Expected to finish

2027-06-01

Last updated by the study team

2026-07-10

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• English-speaking,
• Literate adults,
• Male or female,
• Between the ages of 18 and 55,
• Body Mass Index from 18.5 and 32.0 kg/m2,
• Able to provide written informed consent and perform all study procedures,
• Current recreational cannabis users - must report past 30-day cannabis use and at least 5 exposures in the past year (minimum use criteria); no limit on maximum use,
• Past year history of vaporized or smoked cannabis use to intoxication,
• Past 30-day use of combusted tobacco,
• Not currently seeking treatment for cannabis, tobacco cigarettes, or other drug use,
• If female, a negative pregnancy test and use of an effective form of contraception during study participation (e.g., oral contraceptive, abstinence, barrier method),
• Negative urine drug test for drugs of abuse (other than cannabis) before every Laboratory Session, and
• Otherwise, healthy as determined by the investigator based on medical history, physical examination, vital signs, laboratory chemistries (blood chemistry with liver function tests and hematology, urinalysis, and microscopic evaluation, 12-lead electrocardiogram).

You may not qualify if…

• Physiologic drug dependence on opioids, benzodiazepines, barbiturates, and/or alcohol that would require medical management,
• Clinically significant acute medical problem (e.g., infection) or chronic medical problem requiring daily medication or ongoing medical care (e.g., hypertension, cardiovascular disease, diabetes, respiratory disorders [e.g., asthma, COPD]),
• Existing or significant lung health problems that could interfere with the study,
• Current or history of major psychiatric disorder that would limit the participant's ability to participate in the study (e.g., bipolar disorder),
• Exclusive use of tobacco or cannabis through vapes and Electronic Nicotine Delivery Systems (ENDS) products,
• Currently using daily prescription medications to manage medical conditions or any drug that could interfere with the study (as determined by the study physician),
• Clinically significant abnormal ECG (as determined by study physician/cardiologist),
• Clinically significant abnormal laboratory findings (e.g., liver function tests greater than 3x the upper limits of normal range),
• History of seizure disorder,
• Clinically significant history of head injuries requiring medical management or long-lasting sequelae.

Where it is running

• University of Kentucky — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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