Effects of Melatonin on Sleep Architecture of Critically Ill Patients in the ICU

Starting soon · Phase 4

Conditions studied: Critical Illness, ICU, ICU Hospitalization, Melatonin, Sleep

In brief

This is a pilot study to examine the effects of melatonin on the sleep patterns of critically ill patients. Patients will have their sleep patterns measured with a device attached to their head with a headband then be given a dose of melatonin. Their participation in the study will last two days.

Key facts

Study ID

NCT07691996

Run by

Rutgers, The State University of New Jersey

People needed

30

Starts

2026-09-01

Expected to finish

2028-01-01

Last updated by the study team

2026-07-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years or older, admitted to the ICU
• Expected length of stay of at least 48 hours
• Not mechanically ventilated
• Able to take oral medications.
• Hemodynamically stable as determined by the treating ICU physician
• Able to provide informed consent or have consent provided by a legally -authorized representative.

You may not qualify if…

• Mechanically ventilated
• Currently using melatonin prior to ICU admission,
• Have neurological conditions that may significantly alter sleep architecture, such as traumatic brain injury, stroke, or severe dementia.
• Pregnant or lactating individuals
• Those individuals with a comfort measures-only status

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.