Impact of Various Myopia Management Strategies on Asthenopia Among Pediatric and Adolescent Populations
Starting soon
Conditions studied: Myopia, Visual Fatigue
In brief
Different myopia control interventions have certain effects on ocular asthenopia in children and adolescents. As children and adolescents are in a critical period of visual development, the presence of asthenopia may lead to an earlier onset and increased prevalence of a range of chronic eye diseases and retinal disorders, thereby affecting their physical and mental health as well as future development. However, existing studies have mostly focused on single interventions, lacking a systematic comparison of the effects of multiple myopia control approaches on asthenopia. Therefore, the present study aims to investigate, through a cross-sectional survey, the impact of various myopia control interventions-including conventional spectacles, defocus-inducing spectacles, orthokeratology, low-concentration atropine, red-light therapy, and combined multi-intervention strategies-on asthenopia, to assess the prevalence and severity of asthenopia among users of different interventions, and to compare the differences in their effects on asthenopia. This will provide evidence-based support for the selection of individualised correction strategies in clinical practice and contribute to advancing clinical research on asthenopia in children and adolescents.
Key facts
- Study ID
- NCT07691671
- Run by
- Tianjin Medical University Eye Hospital
- People needed
- 600
- Starts
- 2026-07-05
- Expected to finish
- 2027-04-30
- Last updated by the study team
- 2026-07-09
Who can join
Age: 6 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ① Children and adolescents with myopia attending the Optometry Centre of Tianjin Medical University Eye Hospital;
- Age range 6-18 years, grouped by chronological age at 12 and 13 years into a children's group (6-12 years) and an adolescent group (13-18 years), irrespective of sex; ③ Current use of one or a combination of the following interventions: a. conventional single-vision spectacle lenses; b. defocus-inducing spectacles (multifocal or peripheral defocus design); c. orthokeratology (OK) lenses; d. low-concentration atropine eye drops (0.01%); e. red-light therapy; f. no myopia control intervention; ④ Best-corrected visual acuity (BCVA) ≥ 0.8 on the standard logarithmic visual acuity chart; ⑤ Written informed consent obtained from guardians, and assent obtained from children aged 8 years and older.
You may not qualify if…
- ① Individuals residing in plateau or high-wind areas;
- Individuals with a history of any ophthalmic surgery;
- Individuals diagnosed with psychiatric disorders such as anxiety disorder, depressive disorder, bipolar disorder, or somatic symptom disorder by a psychiatrist, or those who have taken psychoactive medications (e.g., anxiolytics, antidepressants, sedative-hypnotics) within the past 3 months; ④ Individuals with ocular diseases or conditions including keratoconus, strabismus, conjunctivitis, amblyopia, high myopia, glaucoma, cataract, retinal nerve defects, or systemic diseases such as diabetes, hypertension, arthritis, osteoporosis, thyroid disease, chronic migraine, or chronic headache, or those taking medications known to potentially induce asthenopia; ⑤ Others: inability to cooperate with subjective questionnaire completion or objective examinations; or other conditions deemed unsuitable for inclusion by the investigators.
Full record on ClinicalTrials.gov
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