Neoadjuvant HRS-4642 Plus Chemotherapy With or Without Immunotherapy for Pancreatic Cancer
Starting soon · Phase 2
Conditions studied: Pancreatic Cancer
In brief
To evaluate the safety and efficacy of neoadjuvant HRS-4642 plus chemotherapy with or without adebrelimab in patients with pancreatic ductal adenocarcinoma.
Key facts
- Study ID
- NCT07691593
- Run by
- Changhai Hospital
- People needed
- 60
- Starts
- 2026-06-01
- Expected to finish
- 2028-10-01
- Last updated by the study team
- 2026-07-09
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male and female participants aged 18-70 (including those who are 18 and 70 years old)；
- Pathologically or cytologically confirmed ductal adenocarcinoma of the pancreas; and subjects must have at least one measurable lesion as defined by Response Evaluation Criteria in Solid Tumors (RECIST, version 1.1);
- Life expectancy ≥ 12 weeks;
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1;
- Adequate marrow and organ function;
You may not qualify if…
- Prior receipt of any anti-tumor therapy, including but not limited to systemic chemotherapy, radiotherapy, interventional therapy, immunotherapy, targeted therapy, and anti-tumor traditional Chinese medicine therapy;
- Presence of distant metastatic lesions confirmed by imaging;
- Known hypersensitivity to the investigational drug or any of its excipients;
- Presence of any serious or uncontrolled systemic disease;
- History of allogeneic hematopoietic stem cell transplantation or solid organ transplantation;
- Clinically significant acute or chronic pancreatitis;
- Participation in any interventional clinical trial involving drugs or medical devices within 4 weeks prior to the first administration of study treatment;
- Vaccination with live or live-attenuated vaccines within 4 weeks prior to the first dose of the investigational drug;
- Any other condition that, in the judgment of the investigator, makes the subject unsuitable for enrollment.
Full record on ClinicalTrials.gov
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