Dyclonine vs. Tetracaine for Local Anesthesia in Unsedated Gastroscopy
Starting soon · Not applicable
Conditions studied: Gastrointestinal Symptoms
In brief
Gastroscopy is a key diagnostic approach for upper gastrointestinal diseases, but pharyngeal passage of the gastroscopy often causes participants' discomfort. Topical pharyngeal anesthetics are routinely used to alleviate such discomfort. Dyclonine hydrochloride mucilage and tetracaine hydrochloride jelly are the two most commonly used topical pharyngeal anesthetics in clinical practice. Although both agents are widely used, their comparative efficacy in unsedated gastroscopy remains unclear, and high-quality evidence is scarce. This study aims to compare their anesthetic efficacy,participant comfort, and safety.
Key facts
- Study ID
- NCT07691346
- Run by
- General Hospital of Shenyang Military Region
- People needed
- 208
- Starts
- 2026-07-01
- Expected to finish
- 2028-07-01
- Last updated by the study team
- 2026-07-08
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-75 years, of either sex;
- Scheduled for an unsedated gastroscopy;
- American Society of Anesthesiologists (ASA) physical status class I or II;
- Able to understand and cooperate with Visual Analogue Scale (VAS) comfort assessment;
- Willing to provide written informed consent voluntarily.
You may not qualify if…
- Known allergy to the study agents;
- Severe cardiopulmonary disease or hepatic/renal insufficiency;
- Long-term use of sedatives or analgesics, or history of alcohol abuse;
- Pregnancy or lactation;
- Dysphagia or trismus (limited mouth opening);
- Contraindications to upper gastrointestinal endoscopy, including acute perforation and active massive bleeding;
- Mental or cognitive disorders that may preclude cooperation with the procedure;
- Scheduled for therapeutic endoscopic procedures with an anticipated procedure time exceeding 15 minutes;
- Altered upper gastrointestinal anatomy due to prior total gastrectomy, esophagectomy, or subtotal gastrectomy.
Where it is running
- Department of Gastroenterology,General Hospital of Northern Theater Command — Shenyang, Liaoning, China
Full record on ClinicalTrials.gov
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