Prevention of Relapse Through Cognitive Cycling in Patients With Alcohol Use Disorder Following Alcohol Withdrawal

Starting soon · Not applicable

Conditions studied: Cognitive Cycling, Alcohol Use Disorder (AUD), Treatment

In brief

TUA-VelCo is a single-center randomized controlled superiority trial with blinded methodological assessment. Adult patients hospitalized for alcohol withdrawal and meeting the criteria for Alcohol Use Disorder (AUD) according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition will be eligible for inclusion. Participants will be randomly assigned to either a cognitive cycling intervention group or a control group. Participants in the experimental group will receive, in addition to standard addiction care, 12 cognitive cycling sessions (three sessions per week over four weeks). The control group will receive standard care combined with 12 scheduled telephone interviews conducted in parallel with the cognitive cycling sessions. Assessments will be conducted at baseline, 1 month (M1), and 3 months (M3) following hospital discharge. The primary outcome will be the proportion of participants maintaining abstinence at M1. Secondary outcomes include maintenance of abstinence at M3 and within-group and between-group changes in craving, cognitive functioning, insight, psychiatric symptoms, and motivation to maintain abstinent. These outcomes will be assessed using validated scales, including the Obsessive Compulsive Drinking Scale, Montreal Cognitive Assessment, Hanil Alcohol Insight Scale, Hamilton Depression Rating Scale, and Hamilton Anxiety Rating Scale. Biomarkers related to alcohol consumption and neuroplasticity will also be evaluated.

Key facts

Study ID

NCT07690423

Run by

Centre Hospitalier Esquirol

People needed

128

Starts

2026-07-08

Expected to finish

2027-12-01

Last updated by the study team

2026-07-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• adults aged ≥ 18 years
• patients with a diagnosis of alcohol use disorder (AUD) according to DSM-5 criteria
• who have been hospitalized for complex withdrawal and aim to maintain abstinence after discharge
• patients must have preserved cognitive function, defined as a Montreal Cognitive Assessment (MoCA) score ≥ 26
• patients must provide written informed consent

You may not qualify if…

• pregnant women
• patients with unstable psychiatric or somatic conditions
• with a contraindication to physical activity
• participants in structured rehabilitation programs during the first month
• adult under guardianship
• with inability to understand French or provide informed consent
• with major neurocognitive disorder
• with regular physical activity
• participation in another interventional study interfering with outcomes

Full record on ClinicalTrials.gov

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