Effects of Functional Oils on Obesity With Mild Cognitive Impairment

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Conditions studied: Obesity, Mild Cognitive Impairment

In brief

The purpose of this study is to investigate the effects of diacylglycerol (DAG) oil on obesity accompanied by mild cognitive impairment (MCI). Participants aged 45 to 75 years with obesity and MCI will be randomly assigned to two groups: a control group receiving regular rapeseed oil (RSO) and an experimental group receiving rapeseed-based DAG oil. The dietary intervention will last for 6 months. The main goal is to observe whether this functional oil intervention can improve cognitive function and regulate white adipose tissue browning.

Key facts

Study ID

NCT07690384

Run by

Capital Medical University

People needed

100

Starts

2026-07-01

Expected to finish

2027-03-01

Last updated by the study team

2026-07-08

Who can join

Age: 45 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meets the diagnostic criteria for obesity combined with mild cognitive impairment (MCI) (obesity: BMI ≥28.0 kg/m\^2 per the 2022 Chinese Expert Consensus on Obesity Prevention and Treatment; MCI: Montreal Cognitive Assessment [MoCA] score below the education-adjusted cutoff, confirmed by a neurologist)
• Aged 45 to 75 years
• Has not been on a diet or has discontinued dieting for at least 3 months, and has not taken fish oil or similar supplements, or is willing to discontinue such supplements for 3 months prior to the intervention
• Able to accept and consume DAG oil as part of daily diet
• Voluntarily agrees to participate and signs the informed consent form

You may not qualify if…

• History of neuropsychiatric disorders such as stroke, epilepsy, or schizophrenia
• Cognitive impairment attributable to depression, thyroid disease, traumatic brain injury, or drug- or alcohol-induced intoxication
• History of cerebrovascular disease, or cognitive decline due to severe impairment of cardiac, hepatic, pulmonary, or renal function
• Use of antibiotics, health products, or nutritional supplements within 2 weeks prior to fecal sample collection; or gastrointestinal symptoms (trauma, inflammation/infection, abdominal pain, diarrhea, or constipation) or vaccination history within the same period

Where it is running

• Capital Medical University — Beijing, Beijing Municipality, China

Full record on ClinicalTrials.gov

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