How the Body Processes Sugar After Eating, in People With Different Body Weights
Recruiting now · Not applicable
Conditions studied: Obesity & Overweight
In brief
The goal of this clinical trial is to learn how a high-glycaemic meal affects the way the body processes glucose in healthy adults who are either lean or have obesity. The main questions it aims to answer are: Is the polyol pathway (conversion of glucose into sorbitol and fructose) more active after a hyperglycaemic meal? Is this pathway more active in individuals with obesity compared with lean individuals? We will compare people who eat a high-glycaemic meal with those who eat a low-glycaemic meal to see whether meal type changes how glucose is metabolized in the body. Participants will drink a small amount of 14C-labelled glucose so researchers can trace how the body uses glucose, spend one long study day (about 12 hours in the lab) plus short morning visits on days 2 to 4, and undergo repeated measurements, including blood sampling, breath sampling, indirect calorimetry, and complete urine and stool collection for 72 hours. This information will help us understand how glucose is processed in the body and whether people with obesity handle glucose differently than lean individuals.
Key facts
- Study ID
- NCT07690176
- Run by
- Wageningen University
- People needed
- 24
- Starts
- 2026-02-24
- Expected to finish
- 2026-07-30
- Last updated by the study team
- 2026-07-08
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy males and females using contraception during and for 3 months after the study.
- Aged from 18-65 years at the time of signing informed consent
- 18.5 < BMI < 25 kg·m2 or 30< BMI <35 kg·m2
- Must be willing and able to communicate and participate in the whole study, including consumption of 14C-glucose and meals offered during study conduct
- Must have regular bowel movements (i.e. average stool production of ≥1 and ≤3 stools per day)
- Must usually eat 3 meals per day (i.e. breakfast, lunch and dinner)
You may not qualify if…
- Diabetes (Type 1, Type 2, or genetic form of diabetes)
- Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
- HbA1c higher than 53 mmol/mol
- History of clinically significant cardiovascular, renal, hepatic, chronic respiratory or gastro-intestinal disease, immunodeficiency, endocrine, neurological, or psychiatric disorders
- Any diagnosed respiratory disease, such as COPD or asthma
- Any previous motor disorders or disorders in muscle and/or lipid metabolism
- Known severe kidney problems
- Presence of an ulcer in the stomach or gut and/or strong history of indigestion
- Recent or chronic history of diarrhoea
- Known anaemia
- A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia.
- Regular use of dietary supplements (>3 times per week)
- Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)
- History of any drug or alcohol abuse in the past two years
- A confirmed positive alcohol breath test at screening or admission
- Drug use
- Claustrophobia
- Subjects who are on a weight loss diet or following a high calorific/high protein diet to gain weight
- Subjects with functional constipation
- Any known food allergies or intolerances to the 14 major food allergens (celery, cereals containing gluten, crustaceans, eggs, fish, lupin, milk, molluscs, mustard, tree nuts, peanuts, sesame seeds, soybeans, sulphur dioxide and sulphites) or history of a malabsorption syndrome including coeliac disease
- Subjects who have regular gastrointestinal complaints including abdominal pain, stomach upsets and borborygmi or known or suspected irritable bowel syndrome
- Currently taking part in another scientific research
- Having received a product with 14C in the past 12 months
- Pregnant or breastfeeding
- Smoking or having used nicotine-containing products in the 6 months prior to the study.
Where it is running
- Wageningen University and Research — Wageningen, Netherlands (enrolling)
Full record on ClinicalTrials.gov
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