The Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation in Individuals With Tiletamine Use Disorder

Starting soon · Not applicable · Has a placebo group

Conditions studied: Tiletamine Use Disorder, Substance Use Disorder (SUD), Drug Craving

In brief

Participants diagnosed with tiletamine use disorder will be assigned to active or sham taVNS for 5 days. Clinical outcomes ( e.g., behavioral paradigms measures and clinical scales ) and physiological markers (e.g., EEG and ECG) will be evaluated at baseline, post-treatment, and 3-month follow-ups to determine therapeutic efficacy and mechanisms of action.

Key facts

Study ID

NCT07689981

Run by

Shanghai Mental Health Center

People needed

30

Starts

2026-07-01

Expected to finish

2028-01-01

Last updated by the study team

2026-07-08

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-60 years ≥6 years of education[7.1] DSM-5 diagnosis of substance use disorder related to tiletamine Tiletamine use ≥6 months and ≥1 time/week Ability to provide informed consent Willingness to complete follow-up assessments

You may not qualify if…

• Severe cognitive impairment History of epilepsy, brain injury, neurological disease or serious psychiatric disease Use of cognition-enhancing medications within 6 months Other psychoactive substance abuse within past 5 years (except nicotine) Metal implants in the head or severe skin sensitivity

Where it is running

• Shanghai Mental Health Center — Shanghai, Shanghai Municipality, China

Full record on ClinicalTrials.gov

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