Liposomal Bupivacaine vs Standard Bupivacaine for Post-Rhinoplasty Analgesia

Starting soon · Phase 2

Conditions studied: Pain, Postoperative

In brief

The purpose of this study is to find out which pain medication is more effective in reducing pain after nose surgery (rhinoplasty). The investigators are looking to find the best treatment to reduce discomfort and improve the healing process for patients having nose surgery.

Key facts

Study ID

NCT07689162

Run by

Washington University School of Medicine

People needed

45

Starts

2026-07-01

Expected to finish

2027-07-01

Last updated by the study team

2026-07-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (≥18 years) undergoing open rhinoplasty of any indication or complexity (e.g., primary, revision, functional, or cosmetic), including autologous grafting of any type (e.g., septal or costal cartilage) or cadaveric grafting.

You may not qualify if…

• Chronic pain condition requiring ongoing or scheduled analgesic therapy, or any diagnosis associated with chronic pain (e.g., fibromyalgia, chronic headache/migraine, neuropathic pain, complex regional pain syndrome), long-term opioid use (≥3 months, any agent), allergy or contraindication to local anesthetics, acetaminophen, ibuprofen / NSAIDs, tramadol, ketamine, Medrol (methylprednisolone) dose pack
• Concurrent non-nasal surgery planned

Where it is running

• Washington University — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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