ASV and Targeted Fluid Resuscitation in Severe Burns
Starting soon
Conditions studied: Burn, War-Related Injuries, Mechanical Ventilation, Infusion Fluid
In brief
This prospective cohort study will evaluate the use of Adaptive Support Ventilation (ASV) together with targeted fluid resuscitation in adult patients with severe burn injuries requiring mechanical ventilation in the intensive care unit. Patients with extensive burns often develop respiratory failure and require both invasive mechanical ventilation and large-volume fluid resuscitation during the first days after injury. The study will assess whether the combination of ASV and targeted fluid resuscitation is associated with improved oxygenation, respiratory mechanics, fluid balance, and early clinical outcomes during the first 72 hours of intensive care. Clinical data, ventilatory parameters, laboratory results, hemodynamic variables, and fluid resuscitation characteristics will be collected as part of routine clinical care. The findings may help optimize early intensive care management for patients with severe burn injuries and improve future treatment strategies.
Key facts
- Study ID
- NCT07689097
- Run by
- Ukrainian Society of Regional Anesthesia and Pain Therapy
- People needed
- 100
- Starts
- 2026-09-23
- Expected to finish
- 2026-09-23
- Last updated by the study team
- 2026-07-08
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults aged 18 years or older.
- Hospital admission with severe burn injury involving ≥20% total body surface area (TBSA).
- Requirement for invasive mechanical ventilation within 24 hours after admission to the intensive care unit.
- Expected need for mechanical ventilation for at least 48 hours.
- Treatment with Adaptive Support Ventilation (ASV) and targeted fluid resuscitation according to institutional protocols.
- Written informed consent provided by the patient or legally authorized representative, in accordance with local regulations.
You may not qualify if…
- Age younger than 18 years.
- Burn injury involving <20% TBSA.
- Mechanical ventilation initiated more than 24 hours after ICU admission.
- Pregnancy.
- Pre-existing chronic dependence on invasive mechanical ventilation.
- Severe traumatic brain injury requiring a specific ventilation strategy.
- Terminal illness with an expected survival of less than 24 hours.
- Enrollment in another interventional clinical trial that may influence study outcomes.
- Inability to obtain essential clinical data required for study analysis.
Where it is running
- Vinnitsya Regional Clinical Hospital n.a Pirogov — Vinnytsia, Ukraine
Full record on ClinicalTrials.gov
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