Circulatory Exercise After Total Knee Replacement
Starting soon · Not applicable
Conditions studied: Total Knee Replacement, Knee Osteoarthritis, Postoperative Edema, Postoperative Inflammation
In brief
Total knee replacement is commonly associated with early postoperative inflammation, edema, pain, and reduced mobility. This randomized controlled trial will evaluate whether adding a simple circulatory exercise program to standard postoperative rehabilitation reduces early limb edema and inflammatory response after unilateral primary total knee replacement. Participants will be randomized to standard rehabilitation alone or standard rehabilitation plus seated and supine knee-extension exercises with alternating ankle dorsiflexion. The primary endpoint is change in limb edema measured by standardized limb circumference at postoperative day 14.
Key facts
- Study ID
- NCT07688642
- Run by
- Assiut University
- People needed
- 68
- Starts
- 2026-06-16
- Expected to finish
- 2027-05-16
- Last updated by the study team
- 2026-07-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults ≥ 18 years undergoing elective unilateral primary TKR for osteoarthritis.
- Able to provide informed consent.
- Able to perform the exercise (cognitively and physically) prior to discharge.
You may not qualify if…
- Preexisting peripheral vascular disease with severe ischemia or venous insufficiency that limits exercise.
- Contraindication to early active movement per surgeon (e.g., complex surgical fixation limiting motion if present).
- Severe neurological or cognitive impairment preventing instruction adherence.
- Inability to comply with follow-up.
Full record on ClinicalTrials.gov
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