Comparative Evaluation of Sustained meChanical AsPiration Thrombectomy and no Thrombus Modification for Pre-stent Thrombus bUrden Reduction in Patients With Acute Myocardial Infarction Study: the CAPTURE AMI Study
Recruiting now · Phase 2/Phase 3
Conditions studied: STEMI - ST Elevation Myocardial Infarction
In brief
The CAPTURE AMI trial is an investigator-initiated, single-centre, two-arm, randomised controlled trial. Patients aged ≥ 18 years who present with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) will be enrolled after angiographic evidence of a high thrombus burden (TIMI thrombus grade ≥ 4) and meeting the inclusion criteria laid out in section 9.2 will be 1:1 randomised to receive either standalone PCI (Arm 1) or adjunct sustained mechanical thrombectomy + PCI (Arm 2). The CAPTURE AMI study will enrol specifically patients with: A. Evidence of high thrombus burden on coronary angiography (TIMI thrombus grade ≥ 4) B. Culprit in an artery with a diameter of 3.0 mm or more. The trial is designed to evaluate the efficacy of sustained mechanical thrombectomy versus standalone PCI in patients with a large thrombus burden assessed angiographically, with a pre-stent thrombus burden (%) as the primary imaging endpoint.
Key facts
- Study ID
- NCT07687576
- Run by
- Oxford University Hospitals NHS Trust
- People needed
- 60
- Starts
- 2026-07-08
- Expected to finish
- 2028-01-08
- Last updated by the study team
- 2026-07-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Primary PCI patient with ST elevation myocardial infarction
- Angiographic criteria:
- TIMI 0/1 flow at presentation
- Angiographic thrombus score ≥ 4
- Vessel diameter at site of occlusion ≥ 3.0mm (determined by coronary angiography)
You may not qualify if…
- Female participant who is pregnant or lactating
- Unconscious at presentation
- Late STEMI presentation (symptoms onset to wire time > 12 h)
- Clinically/haemodynamically unstable patients
- Known diagnosis of severe renal disease (CKD stage 4-5)
- Suspected spontaneous coronary artery dissection
- Previous CABG
- Previous history on STEMI in the same culprit territory
- Known moderate-severe anaemia (Hb < 9)
Where it is running
- Oxford Heart Centre - John Radcliffe Hospital — Oxford, Oxfordshire, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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