Cholera Control by Case-area Targeted Interventions (CATIs)
Recruiting now · Not applicable
Conditions studied: Cholera, Methodology Study
In brief
To evaluate the effectiveness of the CATI approach among household contacts in the reduction of cumulative incidence of cholera and explore the genome analysis and immune response of V. cholerae antigen from different hotspots in Dhaka city, cholera cases will be enrolled by rapid diagnostic test (RDT) from the diarrhoeal patients coming to icddr,b Dhaka hospital. Hotspots will be defined as the households (HHs) surrounding the RDT-positive cholera case (around 20-40m radius). The 'Case area targeted interventions' (CATI) will be given by administrating Oral Cholera Vaccine (OCV) with either one dose or two doses of OCV 1 month apart among household contacts (≥1-year age and non-pregnant women) and contacts of the contacts residing in the adjacent HHs. The passive surveillance for cholera will be followed using the icddr,b hospital, and other health facilities. Data on each individual's states of the clusters (e.g., susceptible, exposed, infectious, or recovered) will be tracked throughout the 3 years study follow-up.
Key facts
- Study ID
- NCT07685574
- Run by
- International Centre for Diarrhoeal Disease Research, Bangladesh
- People needed
- 68400
- Starts
- 2024-09-05
- Expected to finish
- 2029-12-31
- Last updated by the study team
- 2026-07-06
Who can join
Age: 1 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Some to severe dehydrated diarrheal patient
- Provide signed informed consent form
You may not qualify if…
- Resident in a ward already covered by OCV since 2015
- Vaccination Eligibility
- Inclusion Criteria:
- Aged ≥1 year and non-pregnant
- Meeting the definition of IHC and NHC
- Provide signed informed consent form
- Exclusion criteria:
- History of taking OCV
- Currently suffering from diarrhea
- < 1 year of age
- Pregnant women (verbally confirmed)
- Index case
Where it is running
- International Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b) — Dhaka, Bangladesh (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.