Alpha-Lipoic Acid Supplementation and IVF Outcomes in Women of Advanced Maternal Age

Recruiting now · Not applicable

Conditions studied: Female Infertility Due to Diminished Ovarian Reserve

In brief

Female fertility declines with advancing age, largely because of deteriorating oocyte quality driven by mitochondrial dysfunction and oxidative stress within the ovarian microenvironment. Alpha-lipoic acid (ALA) is a potent antioxidant that crosses cell and mitochondrial membranes, regenerates other antioxidants (vitamin C, vitamin E, glutathione, coenzyme Q10), and supports mitochondrial respiratory chain activity and ATP production. This prospective study will enroll 60 infertile women aged 35-45 years undergoing in vitro fertilization (IVF) treatment. Thirty participants will receive oral ALA 600 mg/day for two months before their IVF cycle, and thirty will proceed directly to IVF without supplementation. The study will compare oocyte and embryo quality, cumulus cell mitochondrial function and metabolic gene expression, and clinical pregnancy and live birth rates between the two groups.

Key facts

Study ID

NCT07685431

Run by

Kaohsiung Veterans General Hospital.

People needed

60

Starts

2026-06-11

Expected to finish

2028-06-30

Last updated by the study team

2026-07-07

Who can join

Age: 35 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age 35-45 years
• BMI 18-35 kg/m²
• Planning to undergo IVF treatment using own oocytes

You may not qualify if…

• Primary ovarian insufficiency
• Azoospermia or severe male-factor infertility in the partner
• Congenital uterine anomaly
• Severe intrauterine adhesion
• Known chromosomal anomaly in either partner
• Malignancy
• Recipient of donor oocytes
• Known hypersensitivity/allergy to alpha-lipoic acid

Where it is running

• Kaohsiung Veterans General Hospital — Kaohsiung City, Taiwan (enrolling)

Full record on ClinicalTrials.gov

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