Influence of Early Wound Healing on the Outcomes of Regenerative Periodontal Surgery

Recruiting now

Conditions studied: Intrabony Periodontal Defect, Wound Healing

In brief

This study investigates whether early post-surgical healing (1-2 weeks) affects the 12-month clinical and radiographic success of periodontal regenerative therapy, and identifies patient-related, site-specific, and technique-related factors associated with optimal early wound healing, in patients with Stage III-IV periodontitis.

Key facts

Study ID

NCT07683962

Run by

University of Roma La Sapienza

People needed

100

Starts

2026-07-01

Expected to finish

2027-10-01

Last updated by the study team

2026-07-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Stage III or IV Periodontitis.
• Presence of at least one deep interproximal infrabony defect (Probing Pocket Depth [PPD] >= 6 mm, radiographic depth >= 3 mm).
• Optimal oral hygiene: Full-Mouth Plaque Score (FMPS) and Full-Mouth Bleeding Score (FMBS) < 15% at the time of surgery.

You may not qualify if…

• Systemic: ASA III-VI classification; uncontrolled diabetes; medications causing gingival overgrowth (e.g., nifedipine, cyclosporine, phenytoin); heavy smokers (>10 cigarettes/day); pregnancy or lactation.
• Local: Third molars; Grade III tooth mobility; inadequate endodontic treatment; teeth undergoing orthodontic treatment; teeth supporting removable or implant-linked fixed prosthetics.

Where it is running

• Sapienza University of Rome, Department of Oral and Maxillofacial Sciences, Section of Periodontology — Rome, Rome, Italy (enrolling)

Full record on ClinicalTrials.gov

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