Sequential PVP-I and FV

Starting soon · Has a placebo group

Conditions studied: Dental Caries

In brief

This prospective cohort study in children will determine if: topical povidone iodine 10% followed by topical fluoride varnish is superior to placebo iodine followed two different varnishes alone to prevent tooth decay (dental caries).

Key facts

Study ID

NCT07683910

Run by

Advantage Silver Dental Arrest, LLC

People needed

393

Starts

2026-09-01

Expected to finish

2029-03-01

Last updated by the study team

2026-07-06

Who can join

Age: 1 and older, up to 2. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Children 6-24 months of age at enrollment. To be eligible a child will have at least 1 erupted tooth that is either sound or has only a d1 (white spot) lesion.

You may not qualify if…

• Previous treatment with fluoride varnish
• Known allergy to iodine
• Diagnosis of thyroid disease
• Chronic, prophylactic use of antibiotics
• Treatment with another investigational drug or other intervention within 30 days preceding the Baseline Visit.
• Visible cavities (d2-4) in the erupted primary teeth
• Presence of intraoral soft tissue pathology (gum boil)
• Parent anticipates the child will move from current city during the next 24 months.

Full record on ClinicalTrials.gov

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