Transcranial Magnetic Stimulation in Laryngeal Dystonia

Starting soon · Not applicable · Has a placebo group

Conditions studied: Laryngeal Dystonia, Spasmodic Dysphonia

In brief

This randomized clinical trial with a crossover design aims to investigate the effects of neuromodulation through repetitive transcranial magnetic stimulation (rTMS) applied to patients diagnosed with laryngeal dystonia. Participants will undergo three experimental conditions: (1) rTMS alone, (2) rTMS combined with speech-language therapy, and (3) sham rTMS combined with speech-language therapy. The order of the conditions will be randomized. Each phase of the protocol will consist of five consecutive sessions. Outcomes will include acoustic vocal quality parameters, perceptual-auditory voice assessment, self-ratings of vocal effort, smoothed cepstral peak prominence measures, and global perceived change following the intervention. It is expected that the study will contribute to a better understanding of the effects of the intervention on vocal outcomes, supporting the optimization and standardization of therapeutic protocols for laryngeal dystonia.

Key facts

Study ID

NCT07683767

Run by

Universidade Federal de Pernambuco

People needed

20

Starts

2026-06-01

Expected to finish

2027-02-01

Last updated by the study team

2026-07-06

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults (≥18 years) of any sex with a confirmed diagnosis of laryngeal dystonia
• Participants not undergoing botulinum toxin treatment at the time of the intervention
• Ability to provide informed consent
• Ability to complete all study assessments and intervention procedures

You may not qualify if…

• Other forms of dystonia
• Vocal fold lesions
• Vocal fold paralysis
• Contraindications to repetitive transcranial magnetic stimulation (rTMS)
• Inability to complete study assessments or intervention procedures

Full record on ClinicalTrials.gov

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