STSC-HybridAPC Trial

Starting soon · Not applicable

Conditions studied: Colon Adenomas, Colon Adenomatous Polyp

In brief

Margin thermal ablation after piecemeal EMR significantly reduces recurrence of large colorectal polyps. As recurrence rates are now low, the key implementation question relates to efficiency and reproducibility of different ablation techniques. This randomized controlled trial compares snare tip soft coagulation (STSC) with Hybrid APC (ERBE), with procedural time as the primary endpoint.

Key facts

Study ID

NCT07682805

Run by

Western Sydney Local Health District

People needed

140

Starts

2027-01-01

Expected to finish

2027-08-15

Last updated by the study team

2026-07-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Undergoing piecemeal EMR of a non-pedunculated colorectal lesion ≥20 mm in size
• Macroscopically complete resection achieved prior to margin ablation (no visible residual adenomatous tissue at the resection base)
• Ability to provide written informed consent

You may not qualify if…

• Lesions requiring en bloc resection by ESD
• Lesions with suspected deep submucosal invasion based on endoscopic assessment (e.g., depressed morphology, non-lifting sign, NICE type 3 pattern, or equivalent advanced imaging criteria)
• Inflammatory bowel disease with active colitis at the lesion site
• Overt invasive carcinoma requiring surgical management
• Pregnancy
• Inability to provide informed consent

Where it is running

• Westmead Hospital — Sydney, New South Wales, Australia

Full record on ClinicalTrials.gov

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