Keloid Pathogenesis And Fibroblast Activation Study

Recruiting now

Conditions studied: Keloids, Fibroblast

In brief

Keloids are benign fibroproliferative skin disorders characterized by excessive fibroblast activation and extracellular matrix deposition. The molecular mechanisms underlying keloid formation remain incompletely understood. This prospective observational study aims to investigate the biological characteristics of keloid tissue by comparing surgically resected keloid specimens with adjacent normal skin obtained from the same patients. Histological and molecular analyses, including histopathology, polymerase chain reaction (PCR), Western blotting, and related laboratory assays, will be performed to identify signaling pathways and key regulatory factors associated with fibroblast activation. The findings may improve the understanding of keloid pathogenesis and identify potential therapeutic targets for future treatment.

Key facts

Study ID

NCT07682636

Run by

The Fourth Affiliated Hospital of Zhejiang University School of Medicine

People needed

20

Starts

2025-05-10

Expected to finish

2028-05-30

Last updated by the study team

2026-07-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Clinically diagnosed with keloid.
• Age 18 years or older.
• Scheduled to undergo surgical treatment at the study hospital.
• Able and willing to provide written informed consent.

You may not qualify if…

• Severe systemic disease.
• History of neurologic disease, alcoholism, postherpetic neuralgia, HIV infection, hypothyroidism, diabetes mellitus, or prior cancer chemotherapy.
• Other skin diseases within 5 cm of the keloid lesion, such as eczema.
• Systemic treatment within 7 days before enrollment or keloid-specific treatment within 6 weeks before enrollment, including intralesional corticosteroid injection, cryotherapy, topical medication, or silicone gel sheeting.
• Hormone or immunosuppressive therapy within 3 months before enrollment.
• Pregnancy or breastfeeding.
• Considered unsuitable for participation by the investigator.
• Refusal to participate in the study.

Where it is running

• The Fourth Affiliated Hospital of Zhejiang University School of Medicine — Jinhua, China (enrolling)

Full record on ClinicalTrials.gov

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