Etiologic Diagnosis Algorithm in Infective Endocarditis

Recruiting now · Not applicable

Conditions studied: Infective Endocarditis, Microbiology

In brief

The goal of this study is to evaluate the impact of a diagnostic algorithm combining culture-based and molecular methods on the frequency of etiotropic antibiotic therapy prescription within 14 days of diagnosis of infective endocarditis

Key facts

Study ID

NCT07682389

Run by

I.M. Sechenov First Moscow State Medical University

People needed

128

Starts

2026-01-20

Expected to finish

2027-02-20

Last updated by the study team

2026-07-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Informed consent,
• Age ≥ 18,
• IE (definite or possible per the 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis)

You may not qualify if…

• Pregnancy/breastfeeding
• Unconfirmed or rejected IE diagnosis,
• Very high risk of death within 14 days due to severe complications of the main or concomitant disease(s), according to the physician's opinion;
• Prior use of antibiotic therapy (except documented treatment failure).

Where it is running

• City Clinical Hospital Named After S. S. Yudin — Moscow, Russia (enrolling)
• City Clinical Hospital №67 Named After L. A. Vorokhobova — Moscow, Russia (enrolling)
• A.N. Bakulev National Medical Research Center for Cardiovascular Surgery of the Russian Ministry of Health — Moscow, Russia

Full record on ClinicalTrials.gov

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