Assessment of Residual Congestion in Acute Decompensated Heart Failure

Recruiting now

Conditions studied: Acute Heart Failure (AHF), Decompensated Chronic Heart Failure

In brief

DESIGN: A prospective, multicenter, observational cohort study including 580 patients admitted for acute decompensated heart failure (ADHF). Ultrasound assessment of congestion (VExUS and LUS) will be performed serially during admission: within 48 hours of admission, at the time diuretic therapy is switched from intravenous to oral, and on the day of discharge. The discharge assessment will serve as the primary predictor. Treating physicians will be blinded to all ultrasound findings. Patients will be followed for 90 days by telephone follow-up and chart review for the primary endpoint, with extended chart review at one year for selected secondary endpoints. AIMS: To determine whether combined ultrasound assessment of venous (VExUS) and pulmonary congestion (LUS) at discharge predicts heart failure readmission and all-cause mortality in patients hospitalized with ADHF. HYPOTHESIS: Abnormal VExUS and/or LUS findings at discharge are associated with a higher risk of heart failure readmission and all-cause mortality after 90 days.

Key facts

Study ID

NCT07682298

Run by

Aarhus University Hospital

People needed

580

Starts

2026-02-15

Expected to finish

2028-11-01

Last updated by the study team

2026-07-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults (≥18 years) admitted with ADHF.
• Clinical evidence of congestion during admission, indicated by ≥1 of the following: pitting peripheral edema, ascites, elevated jugular venous pressure, or radiologic/ultrasound evidence of pulmonary congestion.
• Treatment with ≥40 mg i.v. furosemide or equivalent dose loop diuretic during admission.

You may not qualify if…

• Pregnancy
• Moribund
• Solitary kidney
• Inability to provide written consent

Where it is running

• Aarhus University Hospital - Department of Cardiology — Aarhus, Denmark (enrolling)
• Copenhagen University Hospital, Amager and Hvidovre Hospital - Department of Cardiology — Copenhagen, Denmark
• Zealand University Hospital - Department of Cardiology — Roskilde, Denmark

Full record on ClinicalTrials.gov

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