EFFECT OF PLATELET CONCENTRATE TRANSFUSION ON MICROCIRCULATORY ENDOTHELIAL FUNCTION IN INTENSIVE CARE UNIT

Starting soon

Conditions studied: Thrombocytopenia, Prophylactic Platelet Transfusion, Platelet Transfusion, Endothelial Function

In brief

This study aims to investigate the impact of platelet concentrate (PC) transfusions on endothelial function and the systemic inflammatory response in thrombopenic patients admitted to intensive care who require prophylactic platelet transfusions. Endothelial function will be measured using a laser Doppler device coupled with an acetylcholine iontophoresis system that is applied to the skin.

Key facts

Study ID

NCT07682246

Run by

Assistance Publique - Hôpitaux de Paris

People needed

60

Starts

2026-07-01

Expected to finish

2027-07-01

Last updated by the study team

2026-07-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patient ≥ 18 years of age
• Admitted to intensive care
• Requires prophylactic platelet transfusion for thrombocytopenia
• Enrolled in a social security program
• No objection to participating in the study

You may not qualify if…

• Recent platelet or red blood cell transfusion (< 24 hours)
• Need for urgent red blood cell transfusion due to active bleeding
• Patient under guardianship or conservatorship
• Significant peripheral edema

Where it is running

• Medical Intensive Care Unit, Saint-Antoine Hospital, AP-HP, Paris, France — Paris, France

Full record on ClinicalTrials.gov

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