Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training

Recruiting now · Not applicable

Conditions studied: Smell Loss, Chronic Rhinosinusitis (CRS)

In brief

A research study to assess the baseline olfactory function, mental health status, clinical severity, and immunological profile in patients with smell loss. The impact of a 3-month olfactory training program on smell function, immunological changes, and mental health in patients with smell loss will be evaluated. The primary purpose of this study is to investigate tissue and blood samples to identify molecules that may be related to smell loss, ultimately aiming to develop future treatments for this condition and correlate with cognition.

Key facts

Study ID

NCT07681973

Run by

The Cleveland Clinic

People needed

52

Starts

2025-12-09

Expected to finish

2027-03-31

Last updated by the study team

2026-07-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age less than 18 years-old
• Present to rhinology clinic with CRS with nasal polyps
• Sense of smell loss for any reason (other than trauma or tumor)

You may not qualify if…

• Patients < 18 years of age
• Individuals with unilateral nasal polyps
• Autoimmune diseases
• Ciliary disorders
• Cystic fibrosis
• Smell loss due to tumors or trauma

Where it is running

• The Cleveland Clinic — Cleveland, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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