Amplitude Modulation Frequency Comparison in Kilohertz Transcranial Magnetic Perturbation (kTMP) for Chronic Stroke

Enrolling by invitation · Not applicable

Conditions studied: Stroke

In brief

Stroke is a leading cause of disability with many patients suffering chronic motor function impairments that affect their day-to-day activities. The goal of this proposal is to provide a first assessment of the feasibility and efficacy of an innovative non-invasive brain stimulation system, kTMP, in the treatment of motor impairment following stroke.

Key facts

Study ID

NCT07681102

Run by

Magnetic Tides

People needed

7

Starts

2026-02-10

Expected to finish

2027-06-26

Last updated by the study team

2026-07-06

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18-80 years who have a history of a unilateral stroke ≥ 12 m prior to enrollment.
• Fugl-Meyer Assessment: Upper Extremity (FMA UE) score 20-55.
• Ability to communicate, understand, and give appropriate consent. Participants can follow two-step commands.
• Motor evoked potentials in a hand muscle when stimulating ipsilesional cortex with suprathreshold single-pulse TMS (MEP positive).

You may not qualify if…

• Participants with moderate or severe cognitive impairment (MoCA < 18).
• Participants with sensory deficits FMA-S ≥ 6/12 (with proprioception ≥ 2/4).
• Language impairment or behavioral disorder that interferes with their ability to adhere to the protocol or to provide informed consent.
• Individuals who have a serious uncontrolled medical condition, including but not limited to severe cardiovascular and cardiopulmonary disease.
• Pregnancy or plans to become pregnant during the study period.
• Botulinum toxin injections of the affected upper extremity within 3 months prior to onset of study assessments/testing through the last visit.
• Severe spasticity of the affected upper limb (Modified Ashworth ≥ 3).
• Absolute contraindications related to non-invasive brain stimulation, including:
• History of seizures in the last 12 months while taking anti-epilepsy medication Presence of any metal implants in the head (excluding the mouth), such as cortical stimulators and DBS, clips, coils, shunts, stents or skull plates, cochlear implants Permanent eye liner or head tattoos Implanted electronics such as pacemakers, defibrillators, intrathecal baclofen pumps or vagus nerve stimulator History of experiencing a serious adverse event during a previous transcranial magnetic stimulation (TMS) session

Where it is running

• Magnetic Tides Inc. — Berkeley, California, United States

Full record on ClinicalTrials.gov

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