Postprandial Regulation of Bone Perfusion in Healthy Individuals
Starting soon · Not applicable · Has a placebo group
Conditions studied: Healthy Adult Participants, Bone Physiology, Bone Blood Flow Regulation, Peptide Hormones
In brief
The goal of this clinical trial is to learn whether certain natural hormones - Glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-2, (GLP-2), and amylin - affect blood flow to the bones.
Key facts
- Study ID
- NCT07679516
- Run by
- University of Copenhagen
- People needed
- 15
- Starts
- 2026-07-19
- Expected to finish
- 2028-05-01
- Last updated by the study team
- 2026-07-09
Who can join
Age: 25 and older, up to 50. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 25-50 years.
- BMI between 18.5-30 kg/m2.
- Normal gait.
- Premenopausal (if female).
- Informed consent.
You may not qualify if…
- Bone disease incl. confirmed osteopenia.
- Fracture within the last 6 months at the time of inclusion.
- Amputation or congenital defect of extremities.
- HbA1c>41.9 mmol/mol and/or diagnosed type 1 or type 2 diabetes.
- Any ongoing or prior medication that the investigator evaluates could interfere with the endpoints of the study (e.g. glucocorticoids or other medications that may compromise bone health).
- Pregnancy or breastfeeding (or plans thereof within the study duration).
- Not using effective hormonal contraceptives or an intra uterine device within study duration (e.g. oral contraceptives, transdermal patch, vaginal ring, Depo-Provera injections, Nexplanon implant).
- Ongoing or prior alcohol abuse (defined per ICD-10 classification for alcohol dependence syndrome, F10.21) or daily alcohol intake
- Use of any illicit substance or narcotics within three months of inclusion, including within study duration.
- Any physical or psychological condition that the investigator evaluates would interfere with trial participation.
- Recent (three months prior to inclusion), ongoing or planned weight loss within study duration (weight loss defined as exceeding -5% bodyweight, or intentional hypocaloric dieting)
Where it is running
- Rigshospitalet — Copenhagen, Denmark
Full record on ClinicalTrials.gov
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