Pupillary Light Reflex to Predict Post-Spinal Hypotension in Elective Cesarean Delivery
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Conditions studied: Hypotension, Spinal Anesthesia, Cesarean Delivery
In brief
This prospective observational cohort study investigates whether pre-anesthetic pupillary light reflex (PLR) parameters can predict the risk of hypotension following spinal anesthesia in women undergoing elective cesarean section. Spinal anesthesia-induced hypotension is common, with reported incidence rates of 50-90%, and current predictors such as baseline blood pressure and BMI have limited accuracy. PLR, a sensitive marker of autonomic nervous system balance, may offer a simple, objective, and non-invasive tool for identifying patients at higher risk. The study evaluates pupillary reaction latency and other PLR parameters and correlates them with post-spinal blood pressure changes to determine their predictive value.
Key facts
- Study ID
- NCT07678723
- Run by
- Al-Azhar University
- People needed
- 200
- Starts
- 2026-06-28
- Expected to finish
- 2026-10-31
- Last updated by the study team
- 2026-07-01
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- ASA II Term pregnancy ≥37 weeks Singleton pregnancy Elective cesarean section Age 18-45 years Written informed consent
You may not qualify if…
- Emergency cesarean section Hypertensive disorders Diabetes mellitus Cardiovascular disease Neurological or autonomic disorders Ophthalmic disease Medications affecting autonomic function BMI >40 kg/m² Failed spinal anesthesia
Full record on ClinicalTrials.gov
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