Prevention of Vascular Graft Infection With Hypochlorous Acid

Starting soon · Not applicable

Conditions studied: Vascular Prosthetic Graft Infection

In brief

This is a study of the use of an antibacterial solution, Hypochlorous acid, to prevent infection in vascular surgery bypass grafts. The solution will be used at the end of operations to insert a prosthetic vascular surgery bypass graft, to wash the wound and the vascular bypass graft before the wound is closed. The patients in this study will be undergoing surgery for problems with narrowed and or blocked arteries. The presence or absence of a graft infection will be followed for 12 months following the surgery. Prosthetic vascular graft infections have significant implications for patients with high rates of death and amputation, hence preventing them will have significant benefits for patients and the health care system.

Key facts

Study ID

NCT07678632

Run by

Hamilton Health Sciences Corporation

People needed

500

Starts

2026-08-03

Expected to finish

2028-08-03

Last updated by the study team

2026-07-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing elective or emergent open insertion of prosthetic vascular grafts to the abdominal and/or lower limb vessels, including all prosthetic bypass grafts and patch grafts
• Patients 18 years of age or older
• Able to provide informed consent in English

You may not qualify if…

• Patients undergoing vascular surgery that does not involve the insertion of a prosthetic graft to the abdominal and/or lower limb vessels by an open operation
• Patients under the age of 18 years
• Patients who are unable to provide informed consent in English

Where it is running

• Hamilton Health Sciences — Hamilton, Ontario, Canada

Full record on ClinicalTrials.gov

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