Evaluation of AppleX™ Apple Extract on Anti-Inflammatory and Healthy Aging Effects

Starting soon · Not applicable · Has a placebo group

Conditions studied: Systemic Inflammation (hsCRP), Healthy Aging, Vitality, Healthy Adult Participants

In brief

The goal of this clinical trial is to learn if AppleX™ Apple Extract can help lower systemic inflammation in adults aged 45-70 with signs of low-grade inflammation. It will also look at the extract's effects on fatigue, joint comfort, and biological aging metrics. The main questions it aims to answer are: * Does taking AppleX™ Apple Extract daily lower high-sensitivity C-reactive protein (hsCRP) levels, a key marker of inflammation in the blood? * Does AppleX™ Apple Extract improve participant-reported fatigue and joint comfort? * Does the extract slow down biological or epigenetic aging metrics compared to a placebo? Researchers will compare AppleX™ Apple Extract to a placebo (a look-alike capsule that contains no active ingredients) to see if the apple extract has a measurable anti-inflammatory and healthy aging effect.

Key facts

Study ID

NCT07678346

Run by

Nutraland USA, Inc.

People needed

70

Starts

2026-07-01

Expected to finish

2027-02-01

Last updated by the study team

2026-07-01

Who can join

Age: 45 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 45-70 years at time of enrollment
• Meets questionnaire-based inflammatory enrichment criteria (at least 2 of 5 risk factors, per Section 4.2)
• Non-smoker (no tobacco or nicotine use within 6 months of enrollment)
• Willing and able to maintain stable diet, exercise habits, and supplement use throughout the 24-week study period
• No major medication changes planned during the study period
• Willing to perform home-based DBS collections at T0, T12, and T24
• Access to a smartphone or computer to complete eConsent and online questionnaires
• Able to provide informed consent via the Alethios eConsent platform

You may not qualify if…

• Current use of prescription anti-inflammatory medications including NSAIDs (regular use ≥3x/week), corticosteroids, or DMARDs
• Diagnosis of an autoimmune or inflammatory disease (e.g., rheumatoid arthritis, lupus, IBD, multiple sclerosis)
• Active or unstable cardiovascular disease requiring medication changes during the study period
• History of cancer within the past 5 years (except non-melanoma skin cancer)
• Regular use of supplemental fisetin, quercetin, or resveratrol within 30 days of enrollment
• Pregnancy, breastfeeding, or planning to become pregnant during the study
• Known allergy to apple or apple-derived products
• Body mass index (BMI) >40 kg/m²

Where it is running

• Alethios, Inc. — San Francisco, California, United States

Full record on ClinicalTrials.gov

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