Eye Tracking for Early Identification of Post-ICU Cognitive Impairment

Starting soon

Conditions studied: Post Intensive Care Syndrome (PICS), Cognitive Impairment

In brief

Some patients may have problems with memory, attention, thinking speed, or other cognitive functions after leaving the intensive care unit (ICU). This is called post-ICU cognitive impairment. Early recognition of this problem may help clinicians provide follow-up care and support more promptly. This study will explore whether eye-tracking technology can help identify cognitive impairment in patients soon after ICU discharge. Eye tracking is a non-invasive test that records eye movements while a person looks at images or completes simple visual tasks on a screen. The test does not involve any treatment or change in usual medical care. Participants will be adult patients who have been transferred from the ICU to a general ward. Within 7 days after ICU discharge, participants will complete a cognitive assessment and an eye-tracking test. The study team will also collect relevant clinical information from medical records. Patients will be grouped according to whether they have post-ICU cognitive impairment based on cognitive assessment and clinical judgment. The main purpose of this study is to assess whether information obtained from eye-tracking tests can help clinicians identify possible post-ICU cognitive impairment at an early stage, when used together with standard cognitive assessment. The study will also compare eye movement patterns between the two groups and explore whether eye-tracking measures add useful information beyond standard cognitive assessment.

Key facts

Study ID

NCT07676864

Run by

Shanghai Zhongshan Hospital

People needed

73

Starts

2026-08-01

Expected to finish

2027-05-01

Last updated by the study team

2026-06-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Successfully transferred from the ICU to a general ward after ICU treatment.
• ICU length of stay of at least 24 hours.
• Conscious and able to cooperate with cognitive assessment and eye-tracking tests.
• Willing to participate in the study and able to provide written informed consent.

You may not qualify if…

• Diagnosed with cognitive impairment before ICU admission, such as Alzheimer's disease, based on medical history or previous medical records.
• Previous diagnosis of mental illness or intellectual developmental disorder.
• Severe visual, hearing, or eye disease that prevents completion of cognitive assessment or eye-tracking tasks.
• Severe neurological disease that may affect cognitive function, such as stroke, traumatic brain injury, or intracranial infection.
• Unable to understand or complete the cognitive assessment or eye-tracking tasks due to severe fatigue, marked inattention, communication disorder, or other reasons as assessed by the research staff.

Where it is running

• Zhongshan hospital, Fudan university — Shanghai, China

Full record on ClinicalTrials.gov

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