Effect of Two Different Cryotherapy Irrigation Protocols on Postoperative Endodontic Pain
Starting soon · Not applicable
Conditions studied: Cryotherapy
In brief
The aim of this study is to evaluate the effect of intracanal cryotreated (2-3°C) 2.5% sodium hypochlorite and Saline used throughout the procedure, compared with a room-temperature irrigation protocol with a final cryotreated saline flush or an entirely room temperature irrigation protocol, on postoperative pain in patients with symptomatic irreversible pulpitis and symptomatic apical periodontitis in mandibular molars.
Key facts
- Study ID
- NCT07676409
- Run by
- Cairo University
- People needed
- 45
- Starts
- 2026-06-15
- Expected to finish
- 2027-07-15
- Last updated by the study team
- 2026-06-30
Who can join
Age: 20 and older, up to 40. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age between 20-40 years old.
- Systemically healthy patients (ASA I or II).
- Mature Mandibular molar teeth with :
- Preoperative sharp pain and symptomatic apical periodontitis marked on NRS scale by reading not less than 6.
- Absence or slight widening in the periodontal ligament (PDL).
- Vital response of pulp tissue to cold pulp tester and (ethyl chloride spray).
- Positive response to percussion test.
- Restorable teeth.
- Ability to complete the endodontic treatment in a single visit.
- Positive patient acceptance for participation in the trial. -----------------------------------------------------------------
You may not qualify if…
- Medically compromised patients (ASA III or IV)
- Patients who used NSAIDs in the 24 hours before treatment.
- Patients with two or more adjacent teeth requiring endodontic treatment.
- Pregnant women.
- Patients reporting bruxism or clenching.
- Teeth associated with :
- Acute periapical abscess and/or swelling.
- Greater than grade I mobility or pocket depth greater than 5mm.
- Non-restorable teeth.
- Immature Apex.
- Radiographic evidence of external or internal root resorption, vertical root fracture, perforation, calcification.
Full record on ClinicalTrials.gov
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