Observational, Non-interventional Biomarker and Endotyping Study

Starting soon

Conditions studied: ARDS (Acute Respiratory Distress Syndrome)

In brief

The goal of this observational study is to establish a centralized ARDS biorepository of longitudinal biospecimens and harmonized clinical data, develop unsupervised, therapy-agnostic endotyping algorithms, and develop unsupervised, therapy-specific treatment-prediction algorithms over a 24 month period.

Key facts

Study ID

NCT07675265

Run by

Prenosis, Inc.

People needed

1200

Starts

2026-07-01

Expected to finish

2029-03-01

Last updated by the study team

2026-06-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• ARDS Diagnosis (New Global Definition of ARDS)
• Timing: Acute onset within 7 days
• Radiology: Bilateral pulmonary opacities
• Hypoxia:
• Non-intubated ARDS: PaO2:FIO2<300mmHg or SpO2:FIO2<315 (if SpO2<97%) on HFNO with flow of >30 L/min or NIV/CPAP with at least 5 cm H2O end-expiratory pressure; or Intubated ARDS: PaO2:FIO2<300 mm Hg or SpO2:FIO2<315 (if SpO2<97%)
• ICU admission
• Enrolled within 72 hours of meeting inclusion criteria

You may not qualify if…

• Primary cardiogenic pulmonary edema

Full record on ClinicalTrials.gov

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