Duodenal-jejunal Bypass Sleeve (DJBS) for Obesity and Metabolic Syndrome

Starting soon · Not applicable

Conditions studied: Obesity, Metabolic Syndrome (MetS)

In brief

This study is designed to evaluate the efficacy, safety, and mechanisms of duodenal-jejunal bypass sleeve in patients with obesity

Key facts

Study ID

NCT07675122

Run by

Chinese University of Hong Kong

People needed

20

Starts

2026-08-01

Expected to finish

2029-07-31

Last updated by the study team

2026-06-30

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Body mass index (BMI) ≥27.5kg/m2; or BMI ≥25 kg/m2 with metabolic syndrome

You may not qualify if…

• Patients who have lost more than 5 kg of weight in the past three months
• Patients who have used glucagon-like peptide-1 receptor agonists (GLP-1RAs) in the past three months
• Patients who are currently taking weight loss drugs such as orlistat
• Those who have taken antiplatelet drugs or anticoagulant drugs such as aspirin in the past month
• iron deficiency or iron deficiency anemia
• Gastrointestinal malformations, such as patients with gastrointestinal atresia or other patients who will cause gastrointestinal implantation failure
• Those with a history of cholecystitis and liver abscess
• There is a known infection, and the type of disease and the severity of the infection are not suitable for use by clinicians
• coagulation dysfunction;
• Severe liver and kidney dysfunction, AST /ALT > 2.5 times, total bilirubin > 35 μmol/L, blood creatinine concentration greater than 180 μmol/L
• Patients with ASA IV \& V
• Drug or alcohol abuse addiction or suffering from uncontrollable mental illness
• Duodenal bulb ulcer, gastric ulcer or previous and existing pancreatitis
• Coronary heart disease, angina, cardiac function grade III or above, or pulmonary dysfunction
• Patients who have undergone ERCP before
• Patients with potential bleeding or telangiectasia in the stomach, esophagus, small intestine and other parts
• Have a history of systemic lupus erythematosus, scleroderma
• Those who have contraindications to endoscopy (judged by clinicians)
• Pregnant women or those who are preparing to become pregnant
• Those who are allergic to nickel-titanium
• Any other situation that the clinician deems unsuitable for participation in this product

Where it is running

• Chinese University of Hong Kong — Shatin, Hong Kong
• CUHK Medical Centre — Shatin, Hong Kong

Full record on ClinicalTrials.gov

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