Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Periodontal Disease, Periodontitis (Stage 3), Smoking Behaviors
In brief
This randomized double-blind placebo-controlled clinical trial aims to evaluate the clinical and biochemical effects of omega-3 fatty acids combined with low-dose aspirin as an adjunct to scaling and root planing (SRP) in smoker patients with Stage III periodontitis. The study compares test and control groups regarding periodontal clinical parameters and gingival crevicular fluid interleukin-1 beta (IL-1β) levels Or other inflammatory markers that will be determined later at baseline, 3 months, and 6 months following treatment
Key facts
- Study ID
- NCT07673185
- Run by
- Al-Azhar University
- People needed
- 40
- Starts
- 2025-01-15
- Expected to finish
- 2026-10-30
- Last updated by the study team
- 2026-07-08
Who can join
Age: 30 and older, up to 50. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- - Male or female smokers aged 30 to 50 years.
- Diagnosed with Stage III periodontitis according to the 2017 World Workshop classification.
- Probing pocket depth (PPD) ≥ 5 mm.
- Clinical attachment loss (CAL) ≥ 5 mm.
- Presence of at least 20 natural teeth.
- Willing and able to provide written informed consent.
You may not qualify if…
- - Systemic diseases affecting periodontal health.
- Pregnancy or lactation.
- Periodontal treatment within the previous 6 months.
- Use of antibiotics or anti-inflammatory drugs within the previous 6 months.
- Allergy or hypersensitivity to omega-3 fatty acids or aspirin.
- Long-term anticoagulant therapy.
- History of gastric ulcer or bleeding disorders.
- Participation in another clinical trial within the previous 3 month
Where it is running
- Faculty of Dental Medicine for Girls, Al-Azhar University — Cairo, Egypt (enrolling)
Full record on ClinicalTrials.gov
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