Multimodal Analgesic Regimen for Total Hip Arthroplasty: An Initiative to Minimize Postoperative Opioid Use

Starting soon · Not applicable

Conditions studied: Arthroplasty, Replacement, Hip

In brief

This study examines whether patients undergoing total hip replacement surgery can manage their pain effectively while using fewer opioid pain medications. Participants will be randomly assigned to one of two groups. The first group will receive the standard postoperative pain medication regimen, with all prescriptions sent directly to their pharmacy as usual. The second group will receive the same medications, but their opioid prescription will only be provided as a printed copy rather than being sent directly to the pharmacy, requiring them to choose whether to fill it. All participants will keep a pain journal and complete questionnaires about their medication intake over the first 21 days post-op as well as there function and wellbeing at follow up visits over 3 months. The goal is to determine whether this approach reduces opioid use while still adequately controlling pain after hip replacement surgery.

Key facts

Study ID

NCT07672808

Run by

Henry Ford Health System

People needed

100

Starts

2026-06-01

Expected to finish

2027-05-30

Last updated by the study team

2026-06-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients age 18 and older
• Patients who have undergone total hip arthroplasty by a single, fellowship trained Orthopaedic Surgeon.

You may not qualify if…

• Patients with incomplete data in medical records
• Chronic opioid use in the last 3 months
• Ipsilateral joint surgery in the last year
• Cannot tolerate oral medications
• Swallowing difficulties
• Intolerance to Tylenol, Celebrex, Robaxin, Neurontin, or Tramadol
• History of Alcohol abuse
• History of Drug abuse
• History of Renal impairment
• History of Peptic ulcer disease
• History of GI bleeding
• Illicit narcotic usage in past 6 months
• Chronic liver disease
• Chronic pain syndrome

Where it is running

• Henry Ford Hospital — Detroit, Michigan, United States

Full record on ClinicalTrials.gov

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