Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty

Recruiting now · Phase 1/Phase 2

Conditions studied: Total Knee Arthroplasty (TKA)

In brief

The purpose of this study is to compare same-day discharge rates and recovery outcomes across an adult patient population undergoing elective Total Knee Arthroplasty (TKA), and randomized to receive either spinal block anesthesia or Total IntraVenous Anesthesia (TIVA). Primary Aim: assess same-day discharge rates between study arms (TIVA vs spinal). Secondary Aim: Postoperative comparison of recovery during PostOperative Anesthesia Care Unit (PACU) admission, diagnostic assessment scores; outcomes related to cognition, hemodynamic stability, pain, nausea and vomiting; analysis of IntraOperative electroencephalogram (EEG) monitoring metrics, e.g., total suppression time, average Bi-spectral Index monitor (BIS) value, Spectral Edge Frequency (SEF); ability for Physical Therapy (PT) evaluation prior to discharge; longterm-followup (LTFU), hospital readmission, return to surgery, etc.; adverse event (AE) monitoring.

Key facts

Study ID

NCT07672301

Run by

University of Chicago

People needed

150

Starts

2026-03-11

Expected to finish

2028-06-01

Last updated by the study team

2026-06-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged ≥18 years.
• Scheduled to undergo elective primary total knee arthroplasty (TKA) or robotic total knee arthroplasty (TKA) at the University of Chicago.
• Eligible for same-day discharge (SDD) based on established orthopedic and anesthesia criteria.
• Able to provide written informed consent.
• The ability to comprehend and complete cognitive assessment surveys and questionnaires.
• Consent to receive either Total IntraVenous Anesthesia (TIVA) or Spinal-block Anesthesia in a randomized manner
• No contraindication to either TIVA or spinal anesthesia

You may not qualify if…

• Age <18 years.
• Patients undergoing revision TKA or procedures other than elective primary TKA.
• Ineligibility for same-day discharge as determined by the surgical or anesthesia team.
• Contraindications to either anesthetic technique (e.g., spinal block anesthesia contraindicated due to coagulopathy, infection at puncture site, or patient refusal).
• Known allergy or hypersensitivity to study-related medications.
• Significant pre-existing cognitive impairment or dementia that would preclude valid participation in Short Portable Mental Status Questionnaire (SPMSQ), and 3-Minute Diagnostic Assessment for Confusion Assessment Method (3D-CAM) assessments.
• Severe chronic pain syndromes (e.g., fibromyalgia, centrally mediated pain disorders) that could confound perioperative pain assessment.
• Body mass index (BMI) > 40.
• Prisoners or other vulnerable populations unable to provide voluntary consent.
• Unable to give appropriate consent or difficult to comprehend and complete cognitive assessment surveys and questionnaires

Where it is running

• University of Chicago Medical Center — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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