Neuropathic Dental Pain & DBS

Recruiting now · Not applicable

Conditions studied: Dental Neuralgia, Neuropathic Dental Pain

In brief

This prospective observational study will evaluate pain outcomes in patients with neuropathic dental pain (Atypical Odontalgia/Phantom Tooth Pain) who undergo directional deep brain stimulation (DBS). Participants will complete validated pain, disability, quality-of-life, and mood assessments before surgery and following DBS programming. Directional stimulation will be applied to different thalamic targets to determine whether specific stimulation settings are associated with greater pain relief. The study aims to characterize changes in pain and quality of life following DBS and to identify the stimulation target associated with the greatest reduction in neuropathic dental pain.

Key facts

Study ID

NCT07671950

Run by

University of British Columbia

People needed

5

Starts

2026-01-01

Expected to finish

2028-01-01

Last updated by the study team

2026-06-26

Who can join

Age: 19 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 19 to 80 years.
• Diagnosis of Atypical Odontalgia (AO) (also known as neuropathic dental pain).
• Receiving deep brain stimulation (DBS) treatment for AO due to inadequate response to conventional therapies, including: Pharmacological therapies, and/or Local anesthetics, corticosteroid injections, or nerve blocks.
• Able and willing to provide informed consent.

You may not qualify if…

• Refusal or inability to provide informed consent.
• Known major depression.
• Acute psychosis.

Where it is running

• Vancouver General Hospital — Vancouver, British Columbia, Canada (enrolling)

Full record on ClinicalTrials.gov

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