Angiotensin II for Post Cardiac Surgery Vasoplegia (ANGII_V)

Starting soon · Phase 4

Conditions studied: Vasoplegic Shock, Cardiopulmonary Bypass, Vasoplegia

In brief

The goal of this study is to conduct a prospective trial implementing a modified version of the Emory Protocol for administering ANG II to patients with post cardiac bypass vasoplegia. The main questions we aim to answer are: 1.) does administration of improve mortality, 2.) does the administration of Ang II using the modified protocol shorten the time needed to reach optimal MAP, 3.) does the administration of Ang II using the modified protocol shorten length of stay in the ICU and hospital? Researchers will compare outcomes from the interventional group to historical controls who did not receive Ang II using the modified protocol.

Key facts

Study ID: NCT07671365
Run by: Methodist Healthcare System of San Antonio
People needed: 329
Starts: 2026-07-01
Expected to finish: 2030-08-01
Last updated by the study team: 2026-06-26

Who can join

Age: 18 and older, up to 94. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

In order to be eligible to participate in this study, an individual must meet all of the following criteria:
Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
Male or female, aged 18 or over
Exhibiting vasoplegia or vasoplegic shock following surgeries involving cardiopulmonary bypass
MAP below results below 65mmHg

You may not qualify if…

An individual who meets any of the following criteria will be excluded from participation in this study:
Current use of angiotensin converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs)
Presence of treatment with high-dose glucocorticoids
Pregnancy or lactation
Known allergic reactions to components of the Giapreza, <specify components/allergens>
Febrile illness within <specify time frame>
Treatment with another investigational drug or other intervention within <specify time frame>
Current smoker or tobacco use within <specify timeframe>
Currently receiving VA ECMO for cardiogenic shock
Experiencing uncontrolled hemorrhage
Presenting with burns over 20% or more of body, acute coronary syndrome, bronchial spasms, liver failure, mesenteric ischemia, abdominal aortic aneurysm, or an absolute neutrophil count less than 1000 cubic millimeters

Full record on ClinicalTrials.gov

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