Antibacterial Efficacy of Bioceramic and Calcium Hydroxide Intracanal Medicaments

Recruiting now · Not applicable

Conditions studied: Periapical Periodontitis, Root Canal Infection, Intracanal Medicaments

In brief

This study evaluates the antibacterial effectiveness of two different intracanal medicaments, Bio-C Temp and UltraCal XS , in mandibular molar teeth with chronic apical periodontitis. Intracanal bacterial load is assessed before and after root canal preparation, after intracanal medicament removal, and after final irrigation using droplet digital PCR.

Key facts

Study ID

NCT07671326

Run by

Medipol University

People needed

24

Starts

2025-10-15

Expected to finish

2026-12-01

Last updated by the study team

2026-06-29

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients aged between 18 and 65 years
• Being systemically healthy (ASA I or ASA II)
• Mandibular molar teeth with a radiographically detectable radiolucent lesion in the periapical region
• Willingness of the volunteer or their legal representative to participate in the study by signing the Informed Consent Form

You may not qualify if…

• Patients who have received antibiotics or corticosteroids within the last 3 months
• Patients with systemic diseases
• Teeth that cannot be properly isolated with a rubber dam
• Teeth with periodontal pockets >4 mm and teeth with crown/root fractures
• Individuals who are undergoing or planning to start orthodontic treatment during the study period
• Pregnant or breastfeeding individuals

Where it is running

• Istanbul Medipol University — Istanbul, Istanbul, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.