Effect of Adipose Tissue Derived Autologous Mesenchymal Stem Cell Concentrate on Bone Quality in Mandibular Fracture Healing.

Starting soon · Not applicable

Conditions studied: Mandible Fracture

In brief

* The goal of study is to evaluate the effectiveness of adipose tissue derived-MSCs concentrate application in mandibular fractures. The main question it aims to answer is: Does intervention enhance bone quality, reduce complications and reduce bone regeneration time. * Researchers will compare the effectiveness of adipose tissue derived-MSCs concentrate application with ORIF to ORIF alone to see if MSCs improve healing in mandibular fractures. * Participants will: * Be managed either by adipose tissue derived-MSCs concentrate application with ORIF or ORIF alone. * Undergo CBCT immediately (T1) and 3 months (T4) postoperatively for bone density radiographic evaluation * Visit the clinic postoperatively at one week (T2), one month (T3), three months (T4) for clinical examination

Key facts

Study ID

NCT07671183

Run by

Cairo University

People needed

20

Starts

2026-07-01

Expected to finish

2027-02-01

Last updated by the study team

2026-06-29

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with mandibular fracture.
• Patients who are willing to participate in the study

You may not qualify if…

• Patients with systemic diseases influence bone healing
• Patients with pathological fractures.
• Infection located at the zone to be treated

Full record on ClinicalTrials.gov

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