Platelet-Rich Plasma Versus Standard Care for Episiotomy Wound Healing in Postpartum Women

Starting soon · Not applicable

Conditions studied: Episiotomy, Platelet Rich Plasma (PRP), Wound Healing, Obstetric

In brief

This study looks at whether a treatment made from a patient's own blood, called platelet-rich plasma (PRP), can help heal the cut made during childbirth (episiotomy) better than standard care alone. PRP is prepared by drawing a small blood sample from the patient and spinning it in a centrifuge to concentrate the platelets, which contain natural healing factors. In this study, women who have an episiotomy during vaginal delivery will be randomly assigned to one of two groups: one group will receive a single injection of their own PRP at the wound site right after delivery, and the other group will receive the usual standard wound care. Neither group's care will otherwise differ. Researchers will follow each woman for 6 weeks after delivery, checking how well the wound is healing using a standard scoring tool (REEDA score), along with pain levels, any complications like infection or wound reopening, and how satisfied participants are with their recovery. The goal is to find out whether this simple, low-risk treatment using a woman's own blood can speed up healing and reduce discomfort after childbirth.

Key facts

Study ID

NCT07669285

Run by

Saint Andrew Hospital Constanta

People needed

200

Starts

2026-06-21

Expected to finish

2028-12-30

Last updated by the study team

2026-06-30

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Age ≥ 18 years
• Singular pregnancy, at term (≥ 37 weeks of gestation)
• Vaginal delivery with episiotomy (midline or mediolateral)
• Signed informed consent to participate in the study

You may not qualify if…

• Known coagulation disorders or thrombocytopenia (< 100,000/mm³)
• Severe anemia (hemoglobin < 7 g/dL) at the time of delivery
• Active systemic or local perineal infection at the time of delivery
• Uncontrolled diabetes mellitus or other significant comorbidities affecting wound healing (e.g., autoimmune disease under immunosuppressive treatment) Third- or fourth-degree perineal laceration (extending to the anal sphincter or rectal mucosa) Refusal to participate or inability to provide informed consent

Where it is running

• Saint Andrew Hospital — Constanța, Constanța County, Romania

Full record on ClinicalTrials.gov

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