Acute Normovolemic Hemodilution in Bone Cancer Surgery
Starting soon · Not applicable
Conditions studied: Acute Normovolemic Hemodilution
In brief
Malignant bone tumors often lead to skeletal complications, known as skeletal related events (SRE). These complications mainly include pathological fractures, severe pain, and spinal cord compression. Typically, SRE reduces overall survival rates and is associated with loss of mobility and social functioning, decreased quality of life, and significantly increased healthcare costs. Surgical resection is an important means of treating malignant bone tumors. The main goal of surgical treatment is to maintain the patient's function and mobility by relieving pain, preventing impending fractures and/or nerve compression, or stabilizing pathological fractures. Surgery for malignant bone tumors often requires extensive exploration, osteotomy, and prosthetic reconstruction. The surgery involves significant trauma and excessive bleeding from the wound. Therefore, there is a significant risk of perioperative blood loss and transfusion during surgery for malignant bone tumors. However, blood transfusion also brings transfusion related risks to patients, increases the incidence of postoperative complications, and increases the healthcare burden on patients and society. Acute normovolemic hemodilution (ANH) may help reduce allogeneic red blood cell transfusion. However, There is a lack of high-quality evidence to support the use of ANH in bone cancer surgery.
Key facts
- Study ID
- NCT07669155
- Run by
- Second Affiliated Hospital, Zhejiang University, School of Medicine
- People needed
- 420
- Starts
- 2026-07-01
- Expected to finish
- 2028-05-01
- Last updated by the study team
- 2026-06-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- age 18 more than years;
- undergoing elective bone cancer resection surgery;
- preoperative hemoglobin ≥12 g/dL;
You may not qualify if…
- using a tourniquet;
- BMI<18.5 Kg/m\^2;
- international normalized ratio (INR) >1.5 or platelet count <100 × 10\^9/L;
- cardiopulmonary insufficiency;
- hepatic and renal dysfunction;
- active infectious disease;
- allergy to colloid solution;
- pregnancy;
- declined participation in the study or declined blood transfusion
Where it is running
- The Second Affiliated Hospital of Zhejiang University anesthesiology department — Hangzhou, Zhejiang, China
Full record on ClinicalTrials.gov
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