Intradiscal rhGDF-6 for the Treatment of Lumbar Disc Degeneration

Starting soon · Phase 1/Phase 2

Conditions studied: Disc Degenerative Disease, Back Pain

In brief

The goal of this clinical trial is to find out if a new medicine can help people who have long-lasting back pain caused by damaged spinal discs. The study will also check if the medicine is safe to use. The main questions this study aims to answer are: Is the medicine safe, and what amount works best? Can it reduce long-term back pain? Researchers will test a medicine called CBT005, which contains a healing protein, by injecting it into the spinal discs. They will watch closely to see how people respond to the treatment. Participants will: Receive one study injection into the spinal disc Visit the clinic in person during the first 12 months for checkups Receive phone calls at 24 and 36 months to see how they are doing Still be able to get other pain treatments in the future, including surgery, if needed

Key facts

Study ID

NCT07668466

Run by

Cartago Biotech Pty Ltd

People needed

60

Starts

2026-07-04

Expected to finish

2030-12-01

Last updated by the study team

2026-06-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Persistent low back pain, with at least 3 months of non-surgical therapy, at one symptomatic disc or two symptomatic lumbar disc levels (from L2 to S1).
• MRI scans show Pfirrmann disc degeneration grade 2 to 4 or High Intensity Zone (HIZ) signal change with or without Modic endplate changes.
• Symptoms are a fair bit or a lot bothersome, which require medication or other types of treatments or very disrupting (in response to question*).
• Preoperative Oswestry Disability Index (ODI) score greater than or equal to 30%
• Visual Analog Score for back pain ≥40 mm.
• Any gender, 18 years of age or older
• Clinician diagnosed discogenic pain
• A signed HREC-approved Informed Consent Form
• Able to meet the protocol follow-up schedule and activities
• Females of childbearing potential must have a negative urine/serum pregnancy test at screening (Baseline Visit) and on the day of administration prior to injection *Question defined in full protocol

You may not qualify if…

• People unable to have an MRI
• Abnormal neurological exam at baseline (e.g., chronic radiculopathy)
• Active radicular pain due to anatomical compression such as stenosis or disc herniation
• Symptomatic facet joints and/or severe facet degeneration at the index level or adjacent segments
• Symptomatic Sacro-iliac joint
• MRI findings demonstrate any of the following: Suspected disc appears normal or >50% decrease in disc height or Presence of symptomatic osteophytes
• Any prior lumbar spinal surgeries at suspected symptomatic level; prior surgery at the adjacent levels is acceptable including fusion or arthroplasty, provided the said adjacent level is not independently symptomatic.
• Presence of spondylolisthesis (anterolisthesis, retrolisthesis is acceptable)
• Symptomatic disc degeneration at more than 2 lumbar levels (multi-level disc degeneration based on MRI findings is acceptable with up to two symptomatic level. Only the symptomatic levels will be treated)
• Evidence of active infection
• Immunosuppressive therapy within 3 months prior to investigational product administration
• Either continuous or cumulative use of more than 2 months use in the past 6 months of an oral or systemic steroid. Inhaled steroids are acceptable
• Tumor in the spine
• People with any current and previous cancer. An exemption to this is previous BCCs which have been successfully removed.
• Non-contained herniated nucleus pulposus
• Any prior intradiscal therapies (chemonucleolysis, IDET, intradiscal steroid injection) at the same level being treated, other than rhGDF-6.
• Any non-intradiscal steroid injection less than 2 months prior to administration. Does not include isolated joint injections outside the lumbar region.
• Nerve block injection less than 2 months prior to injection of study medication.
• Known autoimmune disease
• Type 1 Insulin-dependent diabetes mellitus (Type II, non-insulin dependent diabetes mellitus is allowed)
• Pregnant or lactating, or wishes to become pregnant within the first 12 months of the study
• Involved in pending litigation of the spine (including workers compensation cases)
• Demonstrates signs of non-organic pain (e.g., Waddell's Signs)
• Based on clinical history, physical examination and participant presentation, participant has, or is suspected to have, a history of alcohol and/or drug abuse that would preclude participants from providing adequate consent and/or complying with study requirements
• Prisoner

Where it is running

• Spine & Scoliosis Service — Kogarah, New South Wales, Australia

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.